Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Diclofensine hydrochloride (Ro 8-4650 hydrochloride) 是一种高效单胺再摄取抑制剂,在大鼠脑突触体中能够阻断多巴胺 (IC50=0.74 nM)、去甲肾上腺素 (IC50=2.3 nM) 和 5-羟色胺 (IC50=3.7 nM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 196 | 现货 | ||
5 mg | ¥ 455 | 现货 | ||
10 mg | ¥ 763 | 现货 | ||
25 mg | ¥ 1,590 | 现货 | ||
50 mg | ¥ 2,930 | 现货 | ||
100 mg | ¥ 4,350 | 现货 | ||
200 mg | ¥ 6,190 | 现货 |
产品描述 | Diclofensine hydrochloride (Ro 8-4650 hydrochloride) is a Novel Antidepressant, on Peripheral Adrenergic Function |
体外活性 | The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE).?The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake.?PE sensitivity was also enhanced by diclofensine as well as after a single dose of desmethylimipramine (DMI).?In contrast to the common opinion that PE does not interact with the neuronal uptake mechanism, the increase in PE-induced blood pressure response after diclofensine and DMI suggests that PE, a nonbiogenic amine, does indeed enter into the peripheral adrenergic neuron[1]. |
别名 | 4-(3,4-二氯苯)-7-甲氧基-2-甲基-1,2,3,4-四氢异喹啉盐酸盐, Ro 8-4650 hydrochloride |
分子量 | 358.69 |
分子式 | C17H18Cl3NO |
CAS No. | 34041-84-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 52 mg/mL (144.97 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 2.7879 mL | 13.9396 mL | 27.8792 mL | 69.6981 mL |
5 mM | 0.5576 mL | 2.7879 mL | 5.5758 mL | 13.9396 mL | |
10 mM | 0.2788 mL | 1.394 mL | 2.7879 mL | 6.9698 mL | |
20 mM | 0.1394 mL | 0.697 mL | 1.394 mL | 3.4849 mL | |
50 mM | 0.0558 mL | 0.2788 mL | 0.5576 mL | 1.394 mL | |
100 mM | 0.0279 mL | 0.1394 mL | 0.2788 mL | 0.697 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Diclofensine hydrochloride 34041-84-4 GPCR/G Protein Neuroscience Others Dopamine Receptor SLC6A3 DAT Inhibitor Ro 8-4650 inhibit Diclofensine Diclofensine Hydrochloride Dopamine Transporter 4-(3,4-二氯苯)-7-甲氧基-2-甲基-1,2,3,4-四氢异喹啉盐酸盐 Ro 8-4650 Hydrochloride Ro 8-4650 hydrochloride inhibitor